Cholesterol esterification and p53-mediated tumor suppression

• Ngā kaituhi matua: Youjun Li (Author), Michael Karin (Author), Edward V. Prochownik (Author)
• Hōputu: Pukapuka
• I whakaputaina: Open Exploration Publishing Inc., 2023-10-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53's product, p53 regulates many biological processes, including cell metabolism. Cholesterol is a key lipid needed for the maintenance of membrane function and tissue homeostasis...