Optimization of post-insertion method to conjugate Doxil with anti-CD133 monoclonal antibodies: Investigating the specific binding and cytotoxicity to colorectal cancer cells in vitro

• Päätekijät: Karim Dadashi Noshahr (Tekijä), Fahimeh Shamsi (Tekijä), Peter Valtchev (Tekijä), Parviz Kokhaei (Tekijä), Maral Hemati (Tekijä), Mohammad Reza Akbari Eidgahi (Tekijä), Ali Khaleghian (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2020-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

In this paper, Doxil coupled with anti-CD133 monoclonal antibodies made by either routine or optimized post-insertion technique, were compared with respect to their size, drug leakage, release pattern and the number of antibodies conjugated per single liposome. The results demonstrated that the numb...