Estrogen-like and tissue-selective effects of 7-methoxycoumarin from Ficus umbellata (Moraceae): an in vitro and in vivo study

• Main Authors: Stéphane Zingue (Author), Thomas Michel (Author), Chantal Beatrice Magne Nde (Author), Amstrong Nang Njuh (Author), Julia Cisilotto (Author), Derek Tantoh Ndinteh (Author), Colin Clyne (Author), Xavier Fernandez (Author), Tânia Beatriz Creczynski-Pasa (Author), Dieudonné Njamen (Author)
• Format: Book
• Published: BMC, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarins and the respective active metabolite 7-hydroxycoumarin analogs have shown aromatase inhibitory...