Continuous flow Aza-Michael reaction for preparing the fast-acting synthetic opioid drug Remifentanil
Abstract Remifentanil is a modern fentanyl analogue with ultrashort-action granted by an esterase-labile methyl propanoate chain. Here, we present the development of a continuous flow methodology for the key N-alkylation step of remifentanil preparation in a biphasic, "slug-flow" regime. W...
Gorde:
| Egile Nagusiak: | , , |
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| Formatua: | Liburua |
| Argitaratua: |
Universidade de São Paulo,
2023-06-01T00:00:00Z.
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| Sailkapena: |
A1234.567 |
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| Alea 1 | Eskuragarri |