Continuous flow Aza-Michael reaction for preparing the fast-acting synthetic opioid drug Remifentanil
Abstract Remifentanil is a modern fentanyl analogue with ultrashort-action granted by an esterase-labile methyl propanoate chain. Here, we present the development of a continuous flow methodology for the key N-alkylation step of remifentanil preparation in a biphasic, "slug-flow" regime. W...
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Universidade de São Paulo,
2023-06-01T00:00:00Z.
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