Effect of Azelastine on Cardiac Repolarization of Guinea-Pig Cardiomyocytes, hERG K+ Channel, and Human L-type and T-type Ca2+ Channel

• Hoofdauteurs: Mi-Hyeong Park (Auteur), Seung Ho Lee (Auteur), Dae Hyun Chu (Auteur), Kwang Hee Won (Auteur), Bok Hee Choi (Auteur), Han Choe (Auteur), Su-Hyun Jo (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2013-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Azelastine is a second generation histamine H1-receptor antagonist used as an anti-asthmatic and anti-allergic drug that can induce QT prolongation and torsades de pointes. We investigated the acute effects of azelastine on human ether-a-go-go-related gene (hERG) channels, action potential duration...