Effect of Azelastine on Cardiac Repolarization of Guinea-Pig Cardiomyocytes, hERG K+ Channel, and Human L-type and T-type Ca2+ Channel

• Hauptverfasser: Mi-Hyeong Park (Verfasst von), Seung Ho Lee (Verfasst von), Dae Hyun Chu (Verfasst von), Kwang Hee Won (Verfasst von), Bok Hee Choi (Verfasst von), Han Choe (Verfasst von), Su-Hyun Jo (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2013-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Azelastine is a second generation histamine H1-receptor antagonist used as an anti-asthmatic and anti-allergic drug that can induce QT prolongation and torsades de pointes. We investigated the acute effects of azelastine on human ether-a-go-go-related gene (hERG) channels, action potential duration...