Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin

• Главные авторы: Long Wang (Автор), Ting Zhang (Автор), Sha Liu (Автор), Qi Mo (Автор), Nan Jiang (Автор), Qi Chen (Автор), Jing Yang (Автор), Yun-Wei Han (Автор), Jian-Ping Chen (Автор), Fei-Hong Huang (Автор), Hua Li (Автор), Jie Zhou (Автор), Jie-Si Luo (Автор), Jian-Ming Wu (Автор)
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• Опубликовано: Elsevier, 2022-03-01T00:00:00Z.
• Предметы: article
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Thrombocytopenia, a most common complication of radiotherapy and chemotherapy, is an important cause of morbidity and mortality in cancer patients. However, there are still no approved agents for the treatment of radiation- and chemotherapy-induced thrombocytopenia (RIT and CIT, respectively). In th...