Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin

• Main Authors: Long Wang (Author), Ting Zhang (Author), Sha Liu (Author), Qi Mo (Author), Nan Jiang (Author), Qi Chen (Author), Jing Yang (Author), Yun-Wei Han (Author), Jian-Ping Chen (Author), Fei-Hong Huang (Author), Hua Li (Author), Jie Zhou (Author), Jie-Si Luo (Author), Jian-Ming Wu (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thrombocytopenia, a most common complication of radiotherapy and chemotherapy, is an important cause of morbidity and mortality in cancer patients. However, there are still no approved agents for the treatment of radiation- and chemotherapy-induced thrombocytopenia (RIT and CIT, respectively). In th...