Discovery of a novel megakaryopoiesis enhancer, ingenol, promoting thrombopoiesis through PI3K-Akt signaling independent of thrombopoietin

• 主要な著者: Long Wang (著者), Ting Zhang (著者), Sha Liu (著者), Qi Mo (著者), Nan Jiang (著者), Qi Chen (著者), Jing Yang (著者), Yun-Wei Han (著者), Jian-Ping Chen (著者), Fei-Hong Huang (著者), Hua Li (著者), Jie Zhou (著者), Jie-Si Luo (著者), Jian-Ming Wu (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2022-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Thrombocytopenia, a most common complication of radiotherapy and chemotherapy, is an important cause of morbidity and mortality in cancer patients. However, there are still no approved agents for the treatment of radiation- and chemotherapy-induced thrombocytopenia (RIT and CIT, respectively). In th...