Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell lines including A549, PC-3, and SMMC-7721. The results dis...

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Main Authors: Yi Le (Author), Yiyuan Gan (Author), Yihong Fu (Author), Jiamin Liu (Author), Wen Li (Author), Xue Zou (Author), Zhixu Zhou (Author), Zhenchao Wang (Author), Guiping Ouyang (Author), Longjia Yan (Author)
Format: Book
Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
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3rd Floor Main Library

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