Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

• Hoofdauteurs: Yi Le (Auteur), Yiyuan Gan (Auteur), Yihong Fu (Auteur), Jiamin Liu (Auteur), Wen Li (Auteur), Xue Zou (Auteur), Zhixu Zhou (Auteur), Zhenchao Wang (Auteur), Guiping Ouyang (Auteur), Longjia Yan (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell lines including A549, PC-3, and SMMC-7721. The results dis...