Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment

• Prif Awduron: Yi Le (Awdur), Yiyuan Gan (Awdur), Yihong Fu (Awdur), Jiamin Liu (Awdur), Wen Li (Awdur), Xue Zou (Awdur), Zhixu Zhou (Awdur), Zhenchao Wang (Awdur), Guiping Ouyang (Awdur), Longjia Yan (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell lines including A549, PC-3, and SMMC-7721. The results dis...