Formulation of sublingual promethazine hydrochloride tablets for rapid relief of motion sickness

• Main Authors: Hamad S Alyami (Author), Mohamed A. Ibrahim (Author), Mohammad H. Alyami (Author), Eman Z Dahmash (Author), Osaid T. Almeanazel (Author), Thamer S Algahtani (Author), Fars Alanazi (Author), Doaa H. Alshora (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The delivery of antihistaminic agents via the oral route is problematic, especially for elderly patients. This study aimed to develop a sublingual formulation of promethazine hydrochloride by direct compression, and to mask its intensely bitter taste. Promethazine hydrochloride (PMZ) sublingual tabl...