Formulation of sublingual promethazine hydrochloride tablets for rapid relief of motion sickness

• Principais autores: Hamad S Alyami (Autor), Mohamed A. Ibrahim (Autor), Mohammad H. Alyami (Autor), Eman Z Dahmash (Autor), Osaid T. Almeanazel (Autor), Thamer S Algahtani (Autor), Fars Alanazi (Autor), Doaa H. Alshora (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2021-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The delivery of antihistaminic agents via the oral route is problematic, especially for elderly patients. This study aimed to develop a sublingual formulation of promethazine hydrochloride by direct compression, and to mask its intensely bitter taste. Promethazine hydrochloride (PMZ) sublingual tabl...