Cylindromatosis (CYLD), a Deubiquitinase, Attenuates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells

• Main Authors: Tadaatsu Imaizumi (Author), Ryo Hayakari (Author), Shojiro Watanabe (Author), Tomomi Aizawa (Author), Tomoh Matsumiya (Author), Hidemi Yoshida (Author), Kazushi Tsuruga (Author), Shogo Kawaguchi (Author), Hiroshi Tanaka (Author)
• Format: Book
• Published: Karger Publishers, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: Cylindromatosis (CYLD), a deubiquitinase, negatively regulates nuclear factor-κB in various cells. However, its potential roles in glomerular inflammation remain unclear. Because the activation of the Toll-like receptor 3 (TLR3)/type I interferon (IFN) pathways plays a pivotal role...