Magnoflorine Suppresses MAPK and NF-κB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro

Wear particles that detach from the surface of prostheses induce excessive activation of osteoclast and immoderate release of inflammatory cytokines that lead to peri-implant osteolysis and aseptic loosening. In this work, we investigated whether magnoflorine, a quaternary aporphine alkaloid extract...

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Main Authors: Zhenyu Sun (Author), Junkai Zeng (Author), Wenjuan Wang (Author), Xinlin Jia (Author), Qiang Wu (Author), Degang Yu (Author), Yuanqing Mao (Author)
Format: Book
Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
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3rd Floor Main Library

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