Magnoflorine Suppresses MAPK and NF-κB Signaling to Prevent Inflammatory Osteolysis Induced by Titanium Particles In Vivo and Osteoclastogenesis via RANKL In Vitro

• Päätekijät: Zhenyu Sun (Tekijä), Junkai Zeng (Tekijä), Wenjuan Wang (Tekijä), Xinlin Jia (Tekijä), Qiang Wu (Tekijä), Degang Yu (Tekijä), Yuanqing Mao (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Wear particles that detach from the surface of prostheses induce excessive activation of osteoclast and immoderate release of inflammatory cytokines that lead to peri-implant osteolysis and aseptic loosening. In this work, we investigated whether magnoflorine, a quaternary aporphine alkaloid extract...