Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation

• Ngā kaituhi matua: Xueling Liu (Author), Jun Zhang (Author), Jie Li (Author), Chengjie Song (Author), Yuguang Shi (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2022-09-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Objective: Mutations in the copper-zinc superoxide dismutase (SOD1) gene cause familial amyotrophic lateral sclerosis (ALS), a progressive fatal neuromuscular disease characterized by motor neurons death and severe skeletal muscle degeneration. However, there is no effective treatment for this debil...