Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation

• Autori principali: Xueling Liu (Autore), Jun Zhang (Autore), Jie Li (Autore), Chengjie Song (Autore), Yuguang Shi (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2022-09-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Objective: Mutations in the copper-zinc superoxide dismutase (SOD1) gene cause familial amyotrophic lateral sclerosis (ALS), a progressive fatal neuromuscular disease characterized by motor neurons death and severe skeletal muscle degeneration. However, there is no effective treatment for this debil...