Maleimide-Thiol Linkages Alter the Biodistribution of SN38 Therapeutic Microbubbles Compared to Biotin-Avidin While Preserving Parity in Tumoral Drug Delivery

• Główni autorzy: Nicola Ingram (Autor), Radwa H. Abou-Saleh (Autor), Amanda D. Race (Autor), Paul M. Loadman (Autor), Richard J. Bushby (Autor), Stephen D. Evans (Autor), P. Louise Coletta (Autor)
• Format: Książka
• Wydane: MDPI AG, 2024-03-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of thMBs currently uses powerful non-covalent bonding of biotin...