Maleimide-Thiol Linkages Alter the Biodistribution of SN38 Therapeutic Microbubbles Compared to Biotin-Avidin While Preserving Parity in Tumoral Drug Delivery

• 主要な著者: Nicola Ingram (著者), Radwa H. Abou-Saleh (著者), Amanda D. Race (著者), Paul M. Loadman (著者), Richard J. Bushby (著者), Stephen D. Evans (著者), P. Louise Coletta (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2024-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of thMBs currently uses powerful non-covalent bonding of biotin...