Increasing the biorelevance of simulated intestinal fluids for better predictions of drug equilibrium solubility in the fasted upper small intestine

• Auteurs principaux: Nikolaos Koumandrakis (Auteur), Maria Vertzoni (Auteur), Christos Reppas (Auteur)
• Format: Livre
• Publié: International Association of Physical Chemists (IAPC), 2014-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

To date the importance of luminal species other than bile salts and phosphatidylcholine on drug equilibrium solubility in the fasted upper small intestine has not been evaluated. In this communication the importance of fatty acids, cholesterol, and proteins on solubility of four model lipophilic com...