Structure-guided discovery of novel dUTPase inhibitors with anti-Nocardia activity by computational design

• 主要な著者: Zhi-Zheng Wang (著者), Jun Weng (著者), Jing Qi (著者), Xin-Xin Fu (著者), Ban-Bin Xing (著者), Yang Hu (著者), Chun-Hsiang Huang (著者), Chin-Yu Chen (著者), Zigong Wei (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The zoonosis caused by Nocardia is increasing seriously. But commonly used antibiotic drugs often lead to resistance. N. seriolae dUTPase (NsdUTPase) plays a key role in the proliferation of Nocardia, and was regarded as a potent drug target. However, there was little report about the NsdUTPase inhi...