Structure-guided discovery of novel dUTPase inhibitors with anti-Nocardia activity by computational design

• Main Authors: Zhi-Zheng Wang (Author), Jun Weng (Author), Jing Qi (Author), Xin-Xin Fu (Author), Ban-Bin Xing (Author), Yang Hu (Author), Chun-Hsiang Huang (Author), Chin-Yu Chen (Author), Zigong Wei (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The zoonosis caused by Nocardia is increasing seriously. But commonly used antibiotic drugs often lead to resistance. N. seriolae dUTPase (NsdUTPase) plays a key role in the proliferation of Nocardia, and was regarded as a potent drug target. However, there was little report about the NsdUTPase inhi...