Understanding the structure-property relationship of bispecific monoclonal antibodies with Fc site-specific substitutions

• Main Authors: Bo Zhao (Author), Yunlong Zhao (Author), Stephanie Adaniya (Author), Yue Fu (Author), Youmi Moon (Author), Justin Heftel (Author), Shuzhen Chen (Author), Hui Xiao (Author), Ning Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTDevelopment of novel bispecific antibody (bsAb) platforms offers unprecedented opportunities for a wide variety of therapeutic applications. However, the expression and manufacturing of bsAbs with desired structures can be challenging. Owing to the uniqueness of each bsAb platform, more comp...