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Pharmacokinetics and Nephrotoxicity of Polymyxin MRX-8 in Rats: A Novel Agent against Resistant Gram-Negative Bacteria

MRX-8 is a novel polymyxin for carbapenem-resistant Gram-negative infections that has been recently evaluated in Phase I clinical trials. Herein, its pharmacokinetics (PK) and nephrotoxicity in rats are reported for the first time. This study aimed at pre-clinical PK and safety assessments. An LC-MS...

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Main Authors:	Xingyi Qu (Author), Chenxue Guo (Author), Shaojun Liu (Author), Xin Li (Author), Lin Xi (Author), Xiaofen Liu (Author), Jing Zhang (Author)
Format:	Book
Published:	MDPI AG, 2024-04-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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