Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor

• Κύριοι συγγραφείς: Karsten Niefind (Συγγραφέας), Nils Bischoff (Συγγραφέας), Andriy G. Golub (Συγγραφέας), Volodymyr G. Bdzhola (Συγγραφέας), Anatoliy O. Balanda (Συγγραφέας), Andriy O. Prykhod'ko (Συγγραφέας), Sergiy M. Yarmoluk (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2017-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Protein kinase CK2 is associated with a number of human diseases, among them cancer, and is therefore a target for inhibitor development in industry and academia. Six crystal structures of either CK2α, the catalytic subunit of human protein kinase CK2, or its paralog CK2α' in complex with two A...