Involvement of cyclic guanosine monophosphate-dependent protein kinase I in renal antifibrotic effects of serelaxin

• Main Authors: Veronika Wetzl (Author), Elisabeth Schinner (Author), Frieder Kees (Author), Franz Hofmann (Author), Lothar Faerber (Author), Jens Schlossmann (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Kidney fibrosis has shown to be ameliorated through the involvement of cyclic guanosine monophosphate (cGMP) and its dependent protein kinase I (cGKI). Serelaxin, the recombinant form of human relaxin-II, increases cGMP levels and has shown beneficial effects on kidney function in acut...