A polypeptide inhibitor of calcineurin blocks the calcineurin-NFAT signalling pathway in vivo and in vitro

• Autori principali: Ping Wang (Autore), Wenying Li (Autore), Yumeng Yang (Autore), Na Cheng (Autore), Yuchen Zhang (Autore), Nan Zhang (Autore), Yanxia Yin (Autore), Li Tong (Autore), Zhimei Li (Autore), Jing Luo (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition of CN function is an effective treatment for immune diseases. The PVIVIT peptide is an artificial peptide based on the NFAT-PxIxIT motif, which exhibits stronger binding to CN. A bioact...