A polypeptide inhibitor of calcineurin blocks the calcineurin-NFAT signalling pathway in vivo and in vitro

• Main Authors: Ping Wang (Author), Wenying Li (Author), Yumeng Yang (Author), Na Cheng (Author), Yuchen Zhang (Author), Nan Zhang (Author), Yanxia Yin (Author), Li Tong (Author), Zhimei Li (Author), Jing Luo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition of CN function is an effective treatment for immune diseases. The PVIVIT peptide is an artificial peptide based on the NFAT-PxIxIT motif, which exhibits stronger binding to CN. A bioact...