Adiposity is associated with widespread transcriptional changes and downregulation of longevity pathways in aged skeletal muscle

• Main Authors: Mark A. Burton (Author), Elie Antoun (Author), Emma S. Garratt (Author), Leo Westbury (Author), Alica Baczynska (Author), Elaine M. Dennison (Author), Nicholas C. Harvey (Author), Cyrus Cooper (Author), Harnish P. Patel (Author), Keith M. Godfrey (Author), Karen A. Lillycrop (Author), EpiGen Global Research Consortium (Author)
• Formato: Livro
• Publicado em: Wiley, 2023-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Amongst healthy older people, a number of correlates of impaired skeletal muscle mass and function have been defined. Although the prevalence of obesity is increasing markedly in this age group, information is sparse about the particular impacts of obesity on ageing skeletal musc...