Leishmania specific CD4 T cells release IFNγ that limits parasite replication in patients with visceral leishmaniasis.

• Main Authors: Rajiv Kumar (Author), Neetu Singh (Author), Shalini Gautam (Author), Om Prakash Singh (Author), Kamlesh Gidwani (Author), Madhukar Rai (Author), David Sacks (Author), Shyam Sundar (Author), Susanne Nylén (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral leishmaniasis (VL) is associated with increased circulating levels of multiple pro-inflammatory cytokines and chemokines, including IL-12, IFNγ, and TNFα, and elevated expression of IFNγ mRNA in lesional tissue such as the spleen and bone marrow. However, an immunological feature of VL pati...