Leishmania specific CD4 T cells release IFNγ that limits parasite replication in patients with visceral leishmaniasis.

• मुख्य लेखकों: Rajiv Kumar (लेखक), Neetu Singh (लेखक), Shalini Gautam (लेखक), Om Prakash Singh (लेखक), Kamlesh Gidwani (लेखक), Madhukar Rai (लेखक), David Sacks (लेखक), Shyam Sundar (लेखक), Susanne Nylén (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2014-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Visceral leishmaniasis (VL) is associated with increased circulating levels of multiple pro-inflammatory cytokines and chemokines, including IL-12, IFNγ, and TNFα, and elevated expression of IFNγ mRNA in lesional tissue such as the spleen and bone marrow. However, an immunological feature of VL pati...