Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota
Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral ischemic/reperfusion (I/R) injury. The pharmacologically active component and targeting site of crocin remain elusive. In this study, the cerebral-protective e...
Saved in:
Main Authors: | Yue Zhang (Author), Jianliang Geng (Author), Yu Hong (Author), Li Jiao (Author), Shuning Li (Author), Runbin Sun (Author), Yuan Xie (Author), Caixia Yan (Author), Jiye Aa (Author), Guangji Wang (Author) |
---|---|
Format: | Book |
Published: |
Frontiers Media S.A.,
2019-04-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model
by: Fan Xiao, et al.
Published: (2024) -
Evaluation of the antidepressant-like effects of acute and sub-acute administration of crocin and crocetin in mice
by: Bahareh Amin, et al.
Published: (2015) -
Crocetin and crocin decreased cholesterol and triglyceride content of both breast cancer tumors and cell lines
by: Seyed Ali Hashemi, et al.
Published: (2020) -
Modulation of gut microbiota alleviates cerebral ischemia/reperfusion injury in rats by inhibiting M1 polarization of microglia
by: Hai-Jun Li, et al.
Published: (2023) -
Angong Niuhuang Pill ameliorates cerebral ischemia/reperfusion injury in mice partly by restoring gut microbiota dysbiosis
by: Han Zhang, et al.
Published: (2022)