Trimethylamine-N-Oxide Aggravates Kidney Injury via Activation of p38/MAPK Signaling and Upregulation of HuR

• Main Authors: Yunshi Lai (Author), Haie Tang (Author), Xinrong Zhang (Author), Zhanmei Zhou (Author), Miaomiao Zhou (Author), Zheng Hu (Author), Fengxin Zhu (Author), Lei Zhang (Author), Jing Nie (Author)
• Format: Book
• Published: Karger Publishers, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Trimethylamine-N-oxide (TMAO) is an intestinal metabolic toxin, which is produced by gut flora via metabolizing high-choline foods. TMAO is known to increase the risk of atherosclerosis and cardiovascular events in chronic kidney disease (CKD) patients. Objectives: The objective of this...