Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease

• Auteurs principaux: Marsel Lino (Auteur), David Ngai (Auteur), Alison Liu (Auteur), Amanda Mohabeer (Auteur), Cameron Harper (Auteur), Laura-lee Caruso (Auteur), Stephanie A. Schroer (Auteur), Fred Fu (Auteur), Trevor McKee (Auteur), Adria Giacca (Auteur), Minna Woo (Auteur), Michelle P. Bendeck (Auteur)
• Format: Livre
• Publié: Elsevier, 2020-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Objective: Discoidin domain receptor 1 (DDR1) is a collagen binding receptor tyrosine kinase implicated in atherosclerosis, fibrosis, and cancer. Our previous research showed that DDR1 could regulate smooth muscle cell trans-differentiation, fibrosis and calcification in the vascular system in cardi...