Off- and on-target effects of genome editing in mouse embryos

• Main Authors: Shinya AYABE (Author), Kenichi NAKASHIMA (Author), Atsushi YOSHIKI (Author)
• פורמט: ספר
• יצא לאור: The Society for Reproduction and Development, 2018-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-based genome editing technology has enabled manipulation of the embryonic genome. Unbiased whole genome sequencing comparing parents to progeny has revealed that the rate of Cas9-induced mutagenesis in mouse embryos is indistingu...