EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome

EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome

Visceral hypersensitivity and impaired gut barrier are crucial pathophysiology of irritable bowel syndrome (IBS), and injection of lipopolysaccharide or corticotropin-releasing factor, and repeated water avoidance stress simulate these gastrointestinal changes in rat (IBS models). We previously demo...

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Main Authors: Tsukasa Nozu (Author), Saori Miyagishi (Author), Rintaro Nozu (Author), Masatomo Ishioh (Author), Kaoru Takakusaki (Author), Toshikatsu Okumura (Author)
Format: Book
Published: Elsevier, 2021-07-01T00:00:00Z.
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