EMA401, an angiotensin II type 2 receptor antagonist blocks visceral hypersensitivity and colonic hyperpermeability in rat model of irritable bowel syndrome

• मुख्य लेखकों: Tsukasa Nozu (लेखक), Saori Miyagishi (लेखक), Rintaro Nozu (लेखक), Masatomo Ishioh (लेखक), Kaoru Takakusaki (लेखक), Toshikatsu Okumura (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Visceral hypersensitivity and impaired gut barrier are crucial pathophysiology of irritable bowel syndrome (IBS), and injection of lipopolysaccharide or corticotropin-releasing factor, and repeated water avoidance stress simulate these gastrointestinal changes in rat (IBS models). We previously demo...