PU-H71 (NSC 750424): a molecular masterpiece that targets HSP90 in cancer and beyond

• Main Authors: Sameh Saber (Author), Rasha Abdelhady (Author), Mai A. Elhemely (Author), Elsayed A. Elmorsy (Author), Rabab S. Hamad (Author), Mustafa Ahmed Abdel-Reheim (Author), Attalla F. El-kott (Author), Mohammed A. AlShehri (Author), Kareem Morsy (Author), Ali S. AlSheri (Author), Mahmoud E. Youssef (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heat shock protein 90 (HSP90) is a pivotal molecular chaperone with multifaceted roles in cellular health and disease. Herein, we explore how HSP90 orchestrates cellular stress responses, particularly through its partnership with heat shock factor 1 (HSF-1). PU-H71, a selective inhibitor of HSP90, d...