Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells

• Main Authors: Xuejing Shao (Author), Yingqian Chen (Author), Wei Wang (Author), Wenxin Du (Author), Xingya Zhang (Author), Minyi Cai (Author), Shaowei Bing (Author), Ji Cao (Author), Xiaojun Xu (Author), Bo Yang (Author), Qiaojun He (Author), Meidan Ying (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In most acute promyelocytic leukemia (APL) cells, promyelocytic leukemia (PML) fuses to retinoic acid receptor α (RARα) due to chromosomal translocation, thus generating PML/RARα oncoprotein, which is a relatively stable oncoprotein for degradation in APL. Elucidating the mechanism regulating the st...