Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells

• প্রধান লেখক: Xuejing Shao (লেখক), Yingqian Chen (লেখক), Wei Wang (লেখক), Wenxin Du (লেখক), Xingya Zhang (লেখক), Minyi Cai (লেখক), Shaowei Bing (লেখক), Ji Cao (লেখক), Xiaojun Xu (লেখক), Bo Yang (লেখক), Qiaojun He (লেখক), Meidan Ying (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2022-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

In most acute promyelocytic leukemia (APL) cells, promyelocytic leukemia (PML) fuses to retinoic acid receptor α (RARα) due to chromosomal translocation, thus generating PML/RARα oncoprotein, which is a relatively stable oncoprotein for degradation in APL. Elucidating the mechanism regulating the st...