Pharmacokinetic and Drug-Drug Interaction Profiles of the Combination of Tezacaftor/Ivacaftor

• मुख्य लेखकों: Varun Garg (लेखक), Jinshan Shen (लेखक), Chonghua Li (लेखक), Sagar Agarwal (लेखक), Asfiha Gebre (लेखक), Sarah Robertson (लेखक), Jiayin Huang (लेखक), Linda Han (लेखक), Licong Jiang (लेखक), Kristin Stephan (लेखक), Linda T. Wang (लेखक), Julie Lekstrom‐Himes (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2019-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Drug-drug interaction (DDI) studies are described for tezacaftor/ivacaftor, a new cystic fibrosis transmembrane conductance regulator modulator therapy for the treatment of cystic fibrosis. Three phase I DDI studies were conducted in healthy subjects to characterize the DDI profile of tezacaftor/iva...