Pharmacokinetic and Drug-Drug Interaction Profiles of the Combination of Tezacaftor/Ivacaftor

• Main Authors: Varun Garg (Author), Jinshan Shen (Author), Chonghua Li (Author), Sagar Agarwal (Author), Asfiha Gebre (Author), Sarah Robertson (Author), Jiayin Huang (Author), Linda Han (Author), Licong Jiang (Author), Kristin Stephan (Author), Linda T. Wang (Author), Julie Lekstrom‐Himes (Author)
• Format: Book
• Published: Wiley, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-drug interaction (DDI) studies are described for tezacaftor/ivacaftor, a new cystic fibrosis transmembrane conductance regulator modulator therapy for the treatment of cystic fibrosis. Three phase I DDI studies were conducted in healthy subjects to characterize the DDI profile of tezacaftor/iva...