Pharmacokinetic and Drug-Drug Interaction Profiles of the Combination of Tezacaftor/Ivacaftor

• Главные авторы: Varun Garg (Автор), Jinshan Shen (Автор), Chonghua Li (Автор), Sagar Agarwal (Автор), Asfiha Gebre (Автор), Sarah Robertson (Автор), Jiayin Huang (Автор), Linda Han (Автор), Licong Jiang (Автор), Kristin Stephan (Автор), Linda T. Wang (Автор), Julie Lekstrom‐Himes (Автор)
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• Опубликовано: Wiley, 2019-05-01T00:00:00Z.
• Предметы: article
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Drug-drug interaction (DDI) studies are described for tezacaftor/ivacaftor, a new cystic fibrosis transmembrane conductance regulator modulator therapy for the treatment of cystic fibrosis. Three phase I DDI studies were conducted in healthy subjects to characterize the DDI profile of tezacaftor/iva...