Residue-resolved insights into the stabilization of therapeutic proteins by excipients: A case study of two monoclonal antibodies with arginine and glutamate

• Main Authors: Tobias M. Prass (Author), Patrick Garidel (Author), Lars V. Schäfer (Author), Michaela Blech (Author)
• פורמט: ספר
• יצא לאור: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Protein formulation development relies on the selection of excipients that inhibit protein-protein interactions preventing aggregation. Empirical strategies involve screening many excipient and buffer combinations by physicochemical characterization using forced degradation or temperature-induced st...