Residue-resolved insights into the stabilization of therapeutic proteins by excipients: A case study of two monoclonal antibodies with arginine and glutamate

• Principais autores: Tobias M. Prass (Autor), Patrick Garidel (Autor), Lars V. Schäfer (Autor), Michaela Blech (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Protein formulation development relies on the selection of excipients that inhibit protein-protein interactions preventing aggregation. Empirical strategies involve screening many excipient and buffer combinations by physicochemical characterization using forced degradation or temperature-induced st...