TMI-1, TNF-α-Converting Enzyme Inhibitor, Protects Against Paclitaxel-Induced Neurotoxicity in the DRG Neuronal Cells In Vitro

• Main Authors: Yesul Kim (Author), Young-Hoon Jung (Author), Seung-Bin Park (Author), Heekee Kim (Author), Jae-young Kwon (Author), Hae-kyu Kim (Author), Hyeon-Jeong Lee (Author), Soeun Jeon (Author), Eunsoo Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) negatively impacts cancer survivors' quality of life and is challenging to treat with existing drugs for neuropathic pain. TNF-α is known to potentiate TRPV1 activity, which contributes to CIPN. Here, we assessed the role of TMI-1, a...