TMI-1, TNF-α-Converting Enzyme Inhibitor, Protects Against Paclitaxel-Induced Neurotoxicity in the DRG Neuronal Cells In Vitro

• Egile Nagusiak: Yesul Kim (Egilea), Young-Hoon Jung (Egilea), Seung-Bin Park (Egilea), Heekee Kim (Egilea), Jae-young Kwon (Egilea), Hae-kyu Kim (Egilea), Hyeon-Jeong Lee (Egilea), Soeun Jeon (Egilea), Eunsoo Kim (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) negatively impacts cancer survivors' quality of life and is challenging to treat with existing drugs for neuropathic pain. TNF-α is known to potentiate TRPV1 activity, which contributes to CIPN. Here, we assessed the role of TMI-1, a...