Open channel block of Kv1.5 channels by HMQ1611

• Main Authors: Chao Dong (Author), Jiawei Li (Author), Weiguang Ding (Author), Rika Ueda (Author), Xiaolu Xie (Author), Jie Wu (Author), Hiroshi Matsuura (Author), Minoru Horie (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Kv1.5 channels conduct the ultra-rapid delayed rectifier potassium current (IKur). Pharmacological blockade of human Kv1.5 (hKv1.5) has been regarded as an effective treatment of re-entrant based atrial fibrillation, because Kv1.5 is highly expressed in human cardiac atria but scarcely in ventricles...