A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening

• Hauptverfasser: Marc M. J. Da Costa (VerfasserIn), Claire E. Allen (VerfasserIn), Adrian Higginbottom (VerfasserIn), Tennore Ramesh (VerfasserIn), Pamela J. Shaw (VerfasserIn), Christopher J. McDermott (VerfasserIn)
• Format: Buch
• Veröffentlicht: The Company of Biologists, 2014-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Mutations in the superoxide dismutase gene (SOD1) are one cause of familial amyotrophic lateral sclerosis [ALS; also known as motor neuron disease (MND)] in humans. ALS is a relentlessly progressive neurodegenerative disease and, to date, there are no neuroprotective therapies with significant impac...