A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening

• Main Authors: Marc M. J. Da Costa (Author), Claire E. Allen (Author), Adrian Higginbottom (Author), Tennore Ramesh (Author), Pamela J. Shaw (Author), Christopher J. McDermott (Author)
• Format: Book
• Published: The Company of Biologists, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in the superoxide dismutase gene (SOD1) are one cause of familial amyotrophic lateral sclerosis [ALS; also known as motor neuron disease (MND)] in humans. ALS is a relentlessly progressive neurodegenerative disease and, to date, there are no neuroprotective therapies with significant impac...