CD4+CD25hiFOXP3+ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel.

• Main Authors: Yvonne Schmiedel (Author), Ghyslain Mombo-Ngoma (Author), Lucja A Labuda (Author), Jacqueline J Janse (Author), Brechje de Gier (Author), Ayôla A Adegnika (Author), Saadou Issifou (Author), Peter G Kremsner (Author), Hermelijn H Smits (Author), Maria Yazdanbakhsh (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Chronic schistosomiasis is associated with T cell hypo-responsiveness and immunoregulatory mechanisms, including induction of regulatory T cells (Tregs). However, little is known about Treg functional capacity during human Schistosoma haematobium infection. METHODOLOGY:CD4+CD25hiFOXP3+ ce...