Emodin-induced autophagic cell death hinders epithelial-mesenchymal transition via regulation of BMP-7/TGF-β1 in renal fibrosis

• मुख्य लेखकों: Wei Liu (लेखक), Renze Gu (लेखक), Yujiao Lou (लेखक), Chunfeng He (लेखक), Qingchuan Zhang (लेखक), Dongmei Li (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

We aim to explore the effects of emodin and its mechanisms on renal fibrosis (RF). We firstly modeled adriamycin-induced rat RF with unilateral nephrectomy. In vivo and in vitro pharmacological experiments were performed in this study. The presence of collagen deposition was detected by Masson stain...